Literature summary extracted from

Puy, C.; Tucker, E.I.; Wong, Z.C.; Gailani, D.; Smith, S.A.; Choi, S.H.; Morrissey, J.H.; Gruber, A.; McCarty, O.J.
Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates (2013), J. Thromb. Haemost., 11, 1341-1352.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.38	High molecular weight kininogen	-	Homo sapiens
3.4.21.38	long-chain polyphosphate	-	Homo sapiens
3.4.21.38	plasma prekallikrein	-	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.38	corn trypsin inhibitor	-	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.38	factor XI + H2O	Homo sapiens	-	factor XIa + ?	-	?
3.4.21.38	prekallikrein + H2O	Homo sapiens	-	kallikrein + kallikrein prepeptide	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.38	Homo sapiens	P00748	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.38	blood	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.38	factor XI + H2O	-	Homo sapiens	factor XIa + ?	-	?
3.4.21.38	prekallikrein + H2O	-	Homo sapiens	kallikrein + kallikrein prepeptide	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.38	factor XII	-	Homo sapiens
3.4.21.38	FXII	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.21.38	physiological function	factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)